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KMID : 0379119850130030131
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Korean Journal of Mycology
1985 Volume.13 No. 3 p.131 ~ p.139
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Studies on Constituents of the Higher Fungi of Korea (47)
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Kim Byung-Kak
Choi Eung-Chil
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Abstract
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To find antitumor constituents in the shake cultured mycelia of Agaricus campestris, the mycelia were extracted with hot water. Purification of the extract was carried out by ethanol precipitation and by ion exchange chromatography using DEAE-Sephadex A-50. Each fraction obtained during the purification procedure was examined for antitumor activity against sarcoma 180 in ICR mice. The antitumor fraction C was isolated. It showed 56.1% inhibition ratio at a dose of 20 ㎎/㎏/day and consisted of a polysaccharide moiety (45%) and a protein moiety (18%). The polysaccharide was analyzed by G.L.C. and found to contain mannose(42.0%), glucose (25.5%), xylose (16.6%), fucose and galactose. The protein moiety was composed of 17 amino acids. The antitumor fraction A showed immunopotentiating activity by accumulating peritoneal macrophages and by increasing plaque-forming cells in mice.
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